IIIrd
International Symposium on
Heat Shock Proteins in Biology and Medicine
May 23-25, 2006
Charité University
Campus Virchow
Augustenburger Platz
1
Berlin, Germany
CONFERENCE PROGRAM
Conference Room: Weisser Saal
Tuesday May 23, 2006
07:00-08:45
Registration
08:45-09:00
Opening Address
Molecular Chaperones
Session Chairmen: B. Bukau and
R. Tanguay
09:00-09:30 Bernd Bukau, Chaperone network in the yeast cytosol:
Hsp110 is revealed as an HSP70 nucleotide exchange factor
09:30-10:00 Lawrence E. Hightower, What is special
about Hsp70B’?
10:00-10:30 Jacques Landry, HspB8/Bag3: a chaperone complex
involved in macroautophagy
10:30-10:50
Coffee Break
10:50-11:20 David Engelberg, Ha-rasval12 induces HSP70B transcription
via the HSE/HSF1 system but
HSP70B expression is
suppressed
11:20-11:50 Robert Tanguay, Small heat shock chaperones, ageing and
resistance to oxidative stress
11:50-12:20 Carlos M. Farinha, Two
distinct checkpoints control the folding
of normal and mutant CFTR at the endoplasmic
reticulum
12:20-13:30
Lunch
HSP in Inflammation & Immunology
Session Chairmen: A. DeMaio and
G. M. Santoro
13:30-14:00 Antonio DeMaio,
Increase of endocytosis
by heat shock
proteins
14:00-14:30 Susana Fiorentino, HSP70 and HSP70 HOM in tumor cells
treated with Colombians plants
extracts and antitumor
response
14:30-15:00 Laszlo Vigh,
Plasma membrane perturbations acting
to initiate
or refine
heat shock protein
response
15:00-15:30 Gabriella M. Santoro, HSF1 and the control of apoptosis in
chemoresistant cancers
15:30-16:00 John H. Williams, Roles of extracellular heat shock proteins:
a
new sense of danger
16:00-16:20
Coffee Break
HSP in Exercise Immunophysiology
Session Chairmen: A. Asea and
M. A. Fabbraio
16:20-16:50 Alexzander Asea,
Mechanisms by which heat shock proteins
are released from cells:
passive vs active release
mechanisms
16:50-17:20 Mark A. Fabbraio, HSP72 protects against diet-induced insulin
resistance by blocking JNK phosphorylation
17:20-17:50 Elvira
Fehrenbach, HSP70 reaction to exercise in peripheral
blood under normal and hypoxic environmental conditions
17:50-18:20 Peter Csermely, Molecular chaperones and network modules in
cell regulation and targeting
19:00-23:00 Stuart K. Calderwood
Keynote Address and Cocktails
Wednesday May 24, 2006
HSP in Tumor Immunity
Session Chairmen: G. Multhoff
and N. Sato
09:00-09:30 Ralf Dressel, HSP70 activates NK cells
and reduces tumor
growth
09:30-10:00 Tobias Warger,
Interaction of TLR2 and TLR4 ligands with the
N-terminal
domain of Gp96 amplifies
innate and adaptive
10:00-10:30 Valeria Milani, Ex vivo HSP70-peptide-activated
autologous
natural killer cells adoptive therapy: from the bench to the clinic
10:30-10:50
Coffee Break
10:50-11:20 Gabriele Multhoff, IL-2/TKD-activated NK cells as a novel
therapeutic tool for the treatment
of aggressive: HSP70-positive
11:20-11:50 Maya Pandya,
Interaction of human HSP70
with tumor-derived
peptides
11:50-12:20 Norijuki Sato, Heat shock proteins as
a guide for cross-
presentation
12:20-14:30
Lunch and Poster Presentations
HSP in Cardiovascular Disease
Session
Chairmen: V. Milani and A. G. Pockley
14:30-15:00 A. Graham Pockley, Circulating stress proteins and
cardiovascular disease: distinct roles for HSP60 and HSP70
15:00-15:30
Georg Wick, The role of classical
atherosclerosis risk-factors as
primary stressors of vascular endothelial cells
15:30-16:00
Richard J. Heads, Expression and
complex regulation of the
POU domain transcription factors
Brn3a and Brn3b during
cardiac development and regulation of MLC2v and HSP27
target promoters
16:00-16:30 Harm
H. Kampinga, HSP27 protects the heart against atrial
fibrillation
16:30-16:50
Coffee Break
HSF1 Regulation and Role in Disease
Session
Chairmen: L. Sistonen and R. Voellmy
16:50-17:20
Valérie Mezger, HSF-2 regulates radial neuronal migration in
the developing brain cortex
17:50-18:20 Nahid F. Mivechi,
Role of heat shock factors and
heat shock proteins in animal models of human diseases
18:20-18:50 Richard Voellmy, HSP-based gene switches for spatial and
temporal regulation of transgenes
18:50-17:10
Coffee Break
17:10-17:40 Ishwar S. Singh, CXC chemokines: a new family
of heat shock
proteins
17:40-18:10 Lea Sistonen, Post-translational modifications in regulation
of
the
activity and interplay of HSFs
Thursday May 25, 2006
HSP in Cancer
Session Chairmen: S. K. Calderwood
and R. J. Heads
09:00-09:30 Daniel R. Ciocca,
,A pilot clinical study with a therapeutic
vaccine based
on hydroxyapatite
ceramic particles and self-
antigens in cancer patients
09.30-10:00 Ajay Rana,
Balance between survival
and death: a unique role of
MLK3
10:00-10:30 Vishwanie Budhram-Mahadeo, Regulation of HSP27
expression by Brn3a and
Brn3b in different cell
types: role in
breast cancer
10:30-11:00 Vladimir Gabai, HSP27 and HSP72 are involved in protection
of
tumor
cells from genotoxic
stresses
11:00-11:20 Coffee Break
HSP and Cell Death
Session Chairmen: M. Jäättellä
and M. Y. Sherman
11:20-11:50 Ian Brown, Heat
shock proteins and neuroprotection
11:50-12:20 Cinzia Dello Russo, Neuroprotective actions of HSP90 inhibitors
12:20-13:00
Lunch
13:00-13:30 Marja Jäättellä,
Identification
of lens epithelial derived growth
factor (LEDGF/p75) as an Hsp70-2-regulated cancer cell survival
factor
13:30-14:00 Michael Y. Sherman, High expression of heat shock protein
HSP72 allows cancer cells to
avoid P53-dependent and P53-
independent senescence
14:00-14:30 Coffee Break
Hyperthermia and Thermotolerance
Session Chairmen: G. C. Li and
E. A. Repasky
14:30-15:15 Elizabeth A. Repasky, Development of new approaches
using
heat and heat shock proteins
to improve cancer
immunotherapy
15:15-15:45 Gloria C. Li, Hyperthermia, thermotolerance and tumor
oxygenation: potential use of noninvasive
PET imaging
15:45-16:15
Mark D. Hurwitz, HSP70 and prostate cancer:
translational
opportunities from a clinical perspective
16:15-16:45 Chairmen’s Closing Remarks
19:00-23:30 River Cruise and Social Event
